ABSTRACT
In the present study, the gastro protective effect of Feronia elephantum leaves and bark in a model of NSAIDinduced ulcer in rat was analyzed. The lyophilized extract was given by oral gavages (500 mg/kg) three times at 12 hr intervals before administering Indomethacin at 20 mg/kg. Pretreatment with extract significantly decreased the ulcerated area. The volume and acidity of the gastric juice decreased in the pretreated rats. In conclusion, F. elephantum was able to decrease the acidity and increase the mucosal defense in the gastric areas, there by justifying its use as an antiulcerogenic agent.
ABSTRACT
Feronia elephantum belongs to the family Rutaceae is well known in Indian traditional system for its traditional uses. The present investigation was carried out to determine the possible bioactive components of leaves and bark of F. elephantum using GC-MS analysis. 18 components from leaves and 14 components from bark of the above said plant were identified. The prevailing compounds in the ethanol extract of leaves of F. elephantum were 7– Norbornadienyl t-butyl ether (17.26%) , 2–isopropyl–5-methyl–1– heptanol (11.40%), 1– Octanol,2–butyl (8.47%), Phenol, 4–[2–(dimethylamino)–ethyl]– (4.56%), 2,3– Dimethylquinolin-4(1H)–one (3.58%), Ethyl iso–allocholate (1.63%). The ethanol extract of F. elephantum bark contained, 2–Propenenitrile, 3–(3.4-dimethoxyphenyl)–(60.72%) was found as major component followed by phenol, 4–(3-hydroxy-I-propenyl)-2-methoxy–(9.35%), 3-(2-NAcetyl– N-methylaminoethyl)indol (1.15%), cholesta–8,24–dine–3–ol, 4–methyl–(3a'- 4a')– (0.86%) as the major components.